BIOL 306 Cellular Regulatory Mechanisms

Last offered Spring 2013

This course explores the regulation of cellular function and gene expression from a perspective that integrates current paradigms in molecular genetics, intracellular trafficking, genomics, and synthetic biology. Topics include: the roles of protein modifications/interactions and lipids in signal transduction, transcriptional and post-transcriptional control, chromosome instability, cellular degradation pathways, epigenetic mechanisms including gene silencing, programmed cell death, and the appropriation of organelle transport pathways by HIV. A central feature of the course will be discussion of articles from the primary literature, with an emphasis on the molecular bases for a variety of human pathologies such as cancer and aging. The laboratory will consist of a semester-long project that incorporates recombinant DNA techniques, quantitative PCR analysis of transcriptional patterns, bioinformatics, and fluorescence-based approaches to examine defense mechanisms common to the innate immune systems of plants and animals. Evaluation will be based on three take-home tests, in-class discussion of papers, laboratory notebook/report, an independent lab research project, and a grant proposal.
Class Format: lecture/discussion/laboratory
Requirements/Evaluation: evaluation will be based on three tests, in-class discussion of papers, the laboratory notebook, an independent research project, and a grant proposal
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Prerequisites: BIOL 202
Enrollment Preference: Biology majors; not open to first-year students
Department Notes: does not satisfy the distribution requirement in the Biology major
Material and Lab Fees:
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Divisional Attributes: Division III
Other Attributes: BIMO Interdepartmental Electives
Enrollment Limit: 24
Expected Enrollment: 22
Class Number: 3133
BIOL 306 LEC Cellular Regulatory Mechanisms Division 3: Science and Mathematics Lois M. Banta
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