CHEM 343 Fall 2014 Medicinal Chemistry

This course explores the design, development, and function of pharmaceuticals. Fundamental concepts of organic chemistry are extended to the study of pharmacodynamics--the interactions between drugs and their targets that elicit a biological effect--and pharmacokinetics-the study of how the body absorbs, distributes, metabolizes, and eliminates drugs. The path of drug development is traced from discovery of an initial lead, through optimization of structure, to patenting and production. Mechanisms by which drugs target cell membranes, nucleic acids, and proteins are discussed. Drug interactions with enzyme and receptor targets are studied extensively. Specific drug classes selected for detailed analysis may include opiate analgesics, aspirin and other NSAIDs, antibacterial agents, cholinergic & adrenergic agents, CNS agents, as well as antiviral, antiulcer, and anticholesterol drugs.
Class Format: lecture, three hours per week
Requirements/Evaluation: evaluation is based on problem sets, midterm exams, class participation, and a final project
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Prerequisites: CHEM 251 & BIOL 101 or permission of instructor; not open to students who have taken CHEM 111 or CHEM 112
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Divisional Attributes: Division III
Other Attributes: BIMO Interdepartmental Electives, PHLH Biomedical Determinants of Health
Enrollment Limit: 36
Expected Enrollment: 24
Class Number: 1864
CHEM 343 - 01 (F) LEC Medicinal Chemistry Division 3: Science and Mathematics Thomas E. Smith
TR 09:55 AM-11:10 AM Chemistry 202 1864
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