CHEM 343
Medicinal Chemistry Fall 2014
Division III
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Class Details

This course explores the design, development, and function of pharmaceuticals. Fundamental concepts of organic chemistry are extended to the study of pharmacodynamics–the interactions between drugs and their targets that elicit a biological effect–and pharmacokinetics-the study of how the body absorbs, distributes, metabolizes, and eliminates drugs. The path of drug development is traced from discovery of an initial lead, through optimization of structure, to patenting and production. Mechanisms by which drugs target cell membranes, nucleic acids, and proteins are discussed. Drug interactions with enzyme and receptor targets are studied extensively. Specific drug classes selected for detailed analysis may include opiate analgesics, aspirin and other NSAIDs, antibacterial agents, cholinergic & adrenergic agents, CNS agents, as well as antiviral, antiulcer, and anticholesterol drugs.
The Class: Format: lecture, three hours per week
Limit: 36
Expected: 24
Class#: 1864
Grading: yes pass/fail option, yes fifth course option
Requirements/Evaluation: evaluation is based on problem sets, midterm exams, class participation, and a final project
Prerequisites: CHEM 251 & BIOL 101 or permission of instructor; not open to students who have taken CHEM 111 or CHEM 112
Distributions: Division III
Attributes: BIMO Interdepartmental Electives
PHLH Biomedical Determinants of Health

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