CHEM 324 Spring 2015 Enzyme Kinetics and Reaction Mechanisms

Enzymes are complex biological molecules capable of catalyzing chemical reactions with very high efficiency, stereo-selectivity and specificity. The study of enzymatically-catalyzed reactions gives insight into the study of organic reaction mechanisms in general, and into the topic of catalysis especially. This course explores the methods and frameworks for determining enzymatic reaction mechanisms. These methods are based on a firm foundation of organic reaction mechanisms and chemical kinetics. We will investigate the major types of biochemical reactions, focusing on their catalytic mechanisms and how those mechanisms can be elucidated. We will lay the foundation for this mechanistic consideration with discussion of transition state theory, structure-reactivity relationships, steady state and pre-steady kinetics, use of isotopes, genetic modification, and other tools for probing enzymatic reactions. We will also examine the catalytic roles of a variety of vitamins and cofactors.
Class Format: lecture, three hours per week
Requirements/Evaluation: evaluation is based on problem sets, quizzes, midterm exams, a paper, and a final exam
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Prerequisites: CHEM/BIOL/BIMO 321 or permission of instructor
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Divisional Attributes: Division III
Other Attributes: BIMO Interdepartmental Electives
Enrollment Limit: none
Expected Enrollment: 10
Class Number: 3863
CHEM 324 - 01 (S) LEC Enzyme Kinet&Reaction Mechnsms Division 3: Science and Mathematics Cancelled 3863
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