BIOL 413 Fall 2012 Molecular Basis of Biological Clocks

Circadian rhythms have been described in all organisms studied, including humans, a wide range of other eukaryotes and several prokaryotes. With periods of about 24 hours, these rhythms regulate biochemical, cellular, physiological and behavioral activities. Circadian rhythms are generated by cellular clocks--genetically determined internal pacemakers that maintain their oscillations in the absence of environmental cues but may be reset by periodicities in the environment, especially the light-dark cycle. Only recently have we begun to understand how circadian rhythms are generated and controlled at the cellular level. This course will explore the basic biochemical features of biological clocks with the aim of understanding their crucial role in regulating key biological parameters, such as enzyme levels, levels of hormones and other regulatory molecules, and activity and sleep cycles. Class discussions will focus on readings in the original literature.
Class Format: discussion, three hours per week
Requirements/Evaluation: evaluation will be based on class participation and several short papers
Additional Info: not available for the Gaudino option
Additional Info2:
Prerequisites: Biology 202; open to juniors and seniors
Enrollment Preference: senior Biology majors who have not taken a 400-level course
Department Notes: does not satisfy the distribution requirement in the Biology major
Material and Lab Fees:
Distribution Notes:
Divisional Attributes: Division III
Other Attributes: BIMO Interdepartmental Electives
Enrollment Limit: 12
Expected Enrollment: 12
Class Number: 1160
BIOL413-01(F) SEM Molecular Basis Biologic Clock Division 3: Science and Mathematics William DeWitt
TR 09:55 AM-11:10 AM Biology 103A 1160
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