BIOL 418 Spring 2013 Signal Transduction to Cancer

Division of normal cells is a highly regulated process based on input from both intrinsic and extrinsic signals. The cell's response to its environment affects all aspects of cell behavior: proliferation, death, differentiation and migration. The goal of the course is to understand the molecular mechanisms of signal transduction that guide normal cell behavior and how disruptions in this process can lead to cancer. We will focus on the Hedgehog-Gli signaling pathway that is activated in 30% of all known cancers. Genetic studies will serve as an introduction to the components of the pathway, followed by an examination of the molecular mechanisms of signal reception, transduction of intracellular information, scaffolding and transcriptional targets. The final section of the course will investigate how high throughput screens, medicinal chemistry studies and mouse models are used to identify small molecular inhibitors of pathway components. We will consider the effectiveness of these inhibitors in pharmacological studies, clinical trials and potential cancer treatments.
Class Format: seminar
Requirements/Evaluation: four papers
Additional Info: may not be taken pass/fail; not available for Gaudino option
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Prerequisites: Biology 202 or permission of instructor
Enrollment Preference: seniors and then junior
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Divisional Attributes: Division III
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Enrollment Limit: 12
Expected Enrollment: 12
Class Number: 3159
BIOL418-01(S) SEM Signal Transduction to Cancer Division 3: Science and Mathematics Robert M. Savage
TR 09:55 AM-11:10 AM Biology 103A 3159
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