CHEM 326 Spring 2013 Chemical Biology: Discoveries at the Interface

Complex biological behavior is driven by the chemistry of biological molecules including secondary messengers, lipids, proteins, and nucleic acids. Chemists and biologists have recognized that manipulating the chemistry of these systems affords a powerful method to regulate and study cellular activity. The burgeoning field of chemical biology encompasses these efforts. This course introduces the tools of chemical biology, focusing on how small chemical molecules directed at biological systems facilitate answering important questions in biology. Building upon this foundation of chemical and biological techniques, this course will study current applications of these techniques through case studies of recent discoveries. Topics covered include bioconjugation, chemical genetics, extending the genetic code, activity-based probes, and fragment-based drug discovery.
Class Format: lecture, three hours per week
Requirements/Evaluation: evaluation is based on class participation, several short papers, and a final research paper
Additional Info: may not be taken pass/fail; not available for the Gaudino option
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Prerequisites: CHEM/BIOL/BIMO 321
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Divisional Attributes: Division III
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Enrollment Limit: 19
Expected Enrollment: 16
Class Number: 3029
CHEM326-01(S) LEC Chemical Biology Division 3: Science and Mathematics Jimmy A. Blair
MWF 09:00 AM-09:50 AM Chemistry 202 3029
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