BIOL 306
Cellular Regulatory Mechanisms Spring 2015
Division III
This is not the current course catalog

Class Details

This course explores the regulation of cellular function and gene expression from a perspective that integrates current paradigms in molecular genetics, intracellular trafficking, genomics, and synthetic biology. Topics include: the roles of protein modifications/interactions and lipids in signal transduction, transcriptional and post-transcriptional control, chromosome instability, cellular degradation pathways, epigenetic mechanisms including gene silencing, programmed cell death, and the appropriation of organelle transport pathways by HIV. A central feature of the course will be discussion of articles from the primary literature, with an emphasis on the molecular bases for a variety of human pathologies such as cancer and aging. The laboratory will consist of a semester-long project that incorporates recombinant DNA techniques, quantitative PCR analysis of transcriptional patterns, bioinformatics, and fluorescence-based approaches.
The Class: Format: lecture/discussion/laboratory
Limit: 24
Expected: 22
Class#: 3358
Grading: yes pass/fail option, yes fifth course option
Requirements/Evaluation: evaluation will be based on three take-home tests, in-class discussion of papers, laboratory notebook/report, an independent lab research project, and a research paper
Prerequisites: BIOL 202
Enrollment Preferences: Biology majors; not open to first-year students
Unit Notes: does not satisfy the distribution requirement in the Biology major
Distributions: Division III
Attributes: BIMO Interdepartmental Electives

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