CHEM 324
Enzyme Kinetics and Reaction Mechanisms Spring 2022
Division III
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Enzymes are complex biological molecules capable of catalyzing chemical reactions with very high efficiency, stereo-selectivity and specificity. The study of enzymatically-catalyzed reactions gives insight into the study of organic reaction mechanisms in general, and into the topic of catalysis especially. This course explores the methods and frameworks for determining enzymatic reaction mechanisms. These methods are based on a firm foundation of organic reaction mechanisms and chemical kinetics. We will investigate the major types of biochemical reactions, focusing on their catalytic mechanisms and how those mechanisms can be elucidated. We will lay the foundation for this mechanistic consideration with discussion of transition state theory, structure-reactivity relationships, steady state and pre-steady kinetics, use of isotopes, genetic modification, and other tools for probing enzymatic reactions. We will also examine the catalytic roles of a variety of vitamins and cofactors.
The Class: Format: lecture; three hours per week
Limit: 20
Expected: 10
Class#: 3089
Grading: no pass/fail option, yes fifth course option
Requirements/Evaluation: problem sets, quizzes, a midterm exam, a paper, and a final exam
Prerequisites: CHEM/BIOL/BIMO 321 or permission of instructor
Enrollment Preferences: Chemistry majors or BIMO concentrators
Distributions: Division III
Attributes: BIMO Interdepartmental Electives

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